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5ml/10ml Ear Drops
Composition:
Paradichlorobenzene............................................2
%
Benzocaine...........................................................2.7
%
Chlorbutol................................................................5%
Terpentine Oil.......................................................15%
Indications:
Benotol is used in the ear to help
relieve the pain, swelling, and
congestion of some ear infections. It
will not cure the infection itself. An
antibiotic will be needed to treat the
infection.
Description:
Local anesthetic drugs act mainly by
inhibiting
sodium
influx through sodium-specific
ion
channels in the
neuronal
cell
membrane, in particular the
so-called voltage-gated sodium channels.
When the influx of sodium is
interrupted, an
action
potential cannot arise and
signal conduction is inhibited. The
receptor site is thought to be located
at the cytoplasmic (inner) portion of
the sodium channel. Local anesthetic
drugs bind more readily to "open" sodium
channels, thus onset of neuronal
blockade is faster in neurons that are
rapidly firing. This is referred to as
state dependent blockade.
Local anesthetics are weak
bases
and are usually formulated as the
hydrochloride salt to render them
water-soluble. At physiologic
pH
the protonated (ionised) and
unprotonated (unionised) forms of the
molecule exist in an equilibrium but
only the unprotonated molecule diffuses
readily across cell membranes. Once
inside the cell, the lower pH results in
the molecule being protonated, thus
inhibiting its passage back out of the
cell. This is referred to as
"ion-trapping". In the protonated form,
the molecule binds to the local
anaesthetic binding site on the inside
of the ion channel near the cytoplasmic
end.
Acidosis such as caused by wound
infection partly reduces the action of
local anesthetics. This is partly
because most of the anaesthetic is
ionised and therefore unable to cross
the cell membrane
CONTRAINDICATIONS
Known allergy or hypersensitivity to benzocaine.
Dosage: As per the physician’s advice.
Presentations:
MRP
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