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Each tablet contains:
Composition:
Each tablet of COMBIPAR contains:
Ibuprofen …......................... 400
mg
Paracetamol …................... 500 mg
Each tablet of COMBIPAR KID contains:
Ibuprofen …........................ 100
mg
Paracetamol ….................. 125 mg
Therapeutic Indications & Usage :
COMBIPAR is indicated for mild to
moderate pain associated with
inflammation.
Contraindications :
COMBIPAR is not advocated for those
allergic to its ingredients, history of
hypersensitivity to aspirin or other
NSAIDs, aspirin-induced nasal polyps or
bronchospasm, active peptic ulceration
and in severe renal dysfunction.
Precautions & Warnings :
COMBIPAR is to be advocated with
caution in liver & kidney damage,
elderly, patients requiring surgery,
anemia, bronchial asthma, stomatitis,
compromised cardiac function, heart
failure, pre-existing edema, systemic
lupus erythematosus.
Safe use of COMBIPAR in pregnancy and
lactation has not been established.
COMBIPAR should not be preferably
coadministered with other NSAIDs,
corticosteroids, hypoglycemics, digoxin,
lithium, methotrexate, cyclosporine,
coagulants & anticoagulants, bone marrow
suppressants as well as probenecid.
Adverse Reactions :
The adverse reactions due to
ibuprofen (in COMBIPAR) include
cardiovascular manifestations
(tachycardia, flushing & increase in
blood pressure), GI complaints
(particularly epigastric discomfort,
ulceration & perforation), skin changes,
hypersensitivity reactions, renal
affections, aphthous stomatitis,
gingival ulcerations, vision
abnormalities, change in hearing,
epistaxis, pancreatitis, hepatitis and
hematological disturbances.
Side Effects of Paracetamol :
(in COMBIPAR) are rare, and usually
mild. Skin rashes and other
hypersensitivity reactions could occur,
and, on rare occasions, paracetamol
could cause hematological changes.
Drug Interaction :
Corticosteroids along with ibuprofen
can enhance GI damage. Anticoagulants,
heparin or thrombolytic agents are
dangerous during COMBIPAR intake in view
of ibuprofen's potential to cause GI
ulceration / bleeding. Ibuprofen (in
COMBIPAR) can increase the hypoglycemic
action of oral antidiabetics and
insulin.
When given along with antihypertensives
or agents with potential to suppress
bone marrow (like some cephalosporins),
ibuprofen can increase risk of edema and
hematopoietic disturbances respectively.
Ibuprofen (in COMBIPAR) can increase
plasma concentrations of digoxin,
cyclosporine, lithium and methotrexate.
Absorption of paracetamol from COMBIPAR
is increased by concomitant
metoclopramide, and such other agents.
Probenecid can decrease it clearance and
thereby increase paracetamol's plasma
half-life when given along with
COMBIPAR.
Recommended Dosage & Administration :
Adults: 1 COMBIPAR Tab tid/qid, or
as prescribed.
Children (ibuprofen: 20-30 mg/kg
body
weight per day in divided doses;
paracetamol: 10-15 mg/kg body weight
upto 4 times daily)
0.5-1 yr: ½ COMBIPAR KID Tab
tid.
1-2 yrs: ½ COMBIPAR KID Tab tid / qid.
3-7 yrs: 1 COMBIPAR KID Tab tid / qid.
8-12 yrs: 2 COMBIPAR KID Tabs tid / qid.
Presenations :
COMBIPAR Tablets : Blisters of 10s.
COMBIPAR KID Tablets : Blisters of
10s.
Each tablet of DUOFLAM PLUS contains:
Ibuprofen
…................................400 mg
Paracetamol ….........................
500 mg
Caffeine (anhydrous) ….......... 25 mg
Each metered dose canister of DUOFLAM
Spray contains:
:Diclofenac Diethylamine
…................................. 1.16%
w/w
Menthol
…................................................................
5% w/w
Methyl Salicylate
….................................................
10% w/w
Benzyl alcohol
….....................................................
1% w/v
Linseed oil (Oleum Lini)
…................................... 3%
w/w
Excipients & propellant
….....................................
q.s. to 100% w/w
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