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Composition:
Lamivudine.....................................................................150
mg
Zidovudine USP.............................................................300
mg
Indications :
Dectrovir is indicated for the treatment of HIV infection, as
part of combination therapy.
Description:
Lamivudine is a cytosine analog. After lamivudine
is triphosphorylated, it
inhibits HIV reverse
transcription via viral DNA
chain termination and inhibits
RNA- and DNA-dependent DNA
polymerase activities of reverse
transcriptase.
The monophosphate form of
lamivudine is incorporated into
the viral DNA by hepatitis B
virus polymerase, resulting in
DNA chain termination.
Lamivudine is an
analogue of
cytidine. It can
inhibit both types (1 and 2) of
HIV
reverse transcriptase
and also the reverse
transcriptase of
hepatitis B. It needs
to be phosphorylated to its
triphosphate form before it is
active. 3TC-triphosphate also
inhibits cellular
DNA polymerase.
Lamivudine is administered
orally, and it is rapidly
absorbed with a bio-availability
of over 80%. Some research
suggests that lamivudine can
cross the
blood-brain barrier.
Lamivudine is often given in
combination with
zidovudine, with
which it is highly synergistic.
Lamivudine treatment has been
shown to restore zidovudine
sensitivity of previously
resistant HIV. Several
mutagenicity tests show that
lamivudine should not show
mutagenic activity in
therapeutical doses.
Zidovudine
(Retrovir), formerly known as
azidothymidine (AZT), to inhibit
replication of human
immunodeficiency virus HIV).
Zidovudine is a member of a
class of compounds called
dideoxynucleosides. It is a
thymidine analog.
CONTRAINDICATIONS:
Dectrovir
tablets are contraindicated in
patients with previously
demonstrated
clinically significant
hypersensitivity to any of the
components of the product.
Warning
Retrovir (zidovudine) has been
associated with hematologic
toxicity including neutropenia
and severe anemia particularly
in patients with advanced human
immunodeficiency virus (hiv)
disease (see
warnings). prolonged
use of retrovir has been
associated with symptomatic
myopathy.
Dosage:
The recommended oral dose of
Dectrovir for adults and
adolescents (at least 12 years
of age) is one tablet
(containing 150 mg of lamivudine
and 300 mg of zidovudine) twice
daily with or without food or as
per the physician’s advice.
Presentations:
MRP Retailer
Stockist
10 tablets 205.00 164.00
147.60
60 tablets 1122.00
897.60 807.84
(Container)
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