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Each 5 gm contains:
Composition:
Triclosan, Silica, Special Flavour.
Indications :
Twice Brushing with Dr. Dentist, gently removes tough stain,
long lasting mint flavour keeps mouth
clean & fresh, no harsh aprasives or
bleach.
Description:
Triclosan is a broad-spectrum antibacterial agent that
inhibits bacterial fatty acid synthesis
at the enoyl-acyl carrier protein
reductase (FabI) step. Resistance
to triclosan in Escherichia
coli is acquired through a
missense mutation in the fabI
gene that leads to the
expression of FabI[G93V]. The specific
activity and substrate
affinities of FabI[G93V] are similar to
FabI. Two different binding
assays establish that triclosan
dramatically increases the
affinity of FabI for NAD+. In
contrast, triclosan does not increase
the binding of NAD+ to
FabI[G93V]. The x-ray crystal structure
of the FabI-NAD+-triclosan
complex confirms that hydrogen bonds and
hydrophobic interactions
between triclosan and both the protein
and the NAD+ cofactor
contribute to the formation of a stable
ternary complex, with the
drug binding at the enoyl substrate
site. These data show that
the formation of a noncovalent
"bi-substrate" complex
accounts for the effectiveness of
triclosan as a FabI inhibitor
and illustrates that mutations in the
FabI active site that interfere
with the formation of a stable
FabI-NAD+-triclosan ternary
complex acquire resistance to the
drug.
Dosage :
As per the physician’s advice or Dentist
Doctor’s advices.
Presentations :
100 gm
MRP
Retailer Stockist
50.00 40.00
36.00
Wallpaper:
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