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Each tablet contains:
Composition:
Famciclovir
........................................................................250
mg
Famciclovir
........................................................................500
mg
Indications:
Herpes Zoster: Famexavir (famciclovir)
is indicated for the treatment of acute
herpes zoster (shingles), treatment or
suppression of recurrent genital herpes
in immunocompetent patients, and
treatment of recurrent mucocutaneous
herpes simplex infections in
HIV-infected patients.
Description:
Famciclovir undergoes rapid
biotransformation to the active
compound, penciclovir, which is
phosphorylated by viral thymidine kinase
in HSV-1, HSV-2, and VZV-infected cells
to a monophosphate form; this is then
converted to penciclovir triphosphate
and competes with deoxyguanosine
triphosphate to inhibit HSV-2 polymerase
(eg, herpes viral DNA
synthesis/replication is selectively
inhibited)
Warnings/Precautions
Has not been established for use in
initial episodes of genital herpes,
patients with ophthalmic or disseminated
zoster, or in immunocompromised patients
with herpes zoster. Dosage adjustment is
required in patients with renal
insufficiency. Tablets contain lactose;
do not use with galactose intolerance,
severe lactase deficiency, or glucose-galactose
malabsorption syndromes. Safety and
efficacy have not been established in
children <18 years of age.
Contraindications
Hypersensitivity to famciclovir, penciclovir, or any component of the
formulation
Dosage and
Administration
Adults : Herpes zoster: 250 mg three
times daily for 7 days or 750 mg once
daily for 7 days (500 mg three times
daily for 10 days in immunocompromised).
Genital herpes: First episode: 250 mg
three times daily for 5 days; recurrent
infection, 125 mg twice daily for 5 days
(500 mg twice daily for 7 days in all
episodes in immunocompromised).
Suppression of recurrent genital herpes:
250 mg twice daily (500 mg twice daily
in HIV patients) interrupted every 6-12
months. Children: Not recommended
Interactions
Uricosurics: probenicid possibly
reduces famciclovir excretion thereby
increasing plasma concentration
Dosage:
As per the physician’s advice.
Presentations:
MRP Retailer Stockist
10
tablets
315.00 252.00 226.80
7 tablets 280.75
224.60 202.14
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