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Composition:
Frusemide
..........................................................................40
mg
Indications:
Mild to moderate Hypertension
Description:
Frusemide can inhibit various indirectly acting
bronchoconstrictor stimuli in asthmatic
patients. Frusemide also modulate airway
neurotransmission in some species but
there are no data on the
effect of loop diuretics on
neurotransmission in man.The mechanism
of action of frusemide on airway
nerves remains unclear: inhibition
of the Na-K-Cl cotransporter is a
possibility and, for frusemide,
release of endogenous cyclooxygenase
products may be involved. Carbonic
anhydrase inhibition, on the other hand,
is unlikely to be a factor.
This study has provided evidence to support the hypothesis
that frusemide inhibit sensory nerve
activation to reduce the itch and flare
responses induced by histamine in human
skin in vivo. It is likely that
inhibition of a Na [+]/K [+]/2Cl [-]
cotransporter in the sensory nerve
membrane is a possible mechanism of
action.
The use of frusemide led to symptomatic
improvement shortly after its
administration. They proposed that a 'diuresis'
was occurring through the skin, as their
patients did not exhibit increased urine
output before the improvement was noted,
but instead seemed to sweat excessively.
The effect of frusemide on veins has
been shown to be mostly an indirect one,
but frusemide may also display direct
venodilator properties.
Dosage
Mild to moderate
Hypertension: 40-80 mg once or twice
daily. Cardiac, pulmonary, renal,
hepatic and cerebral oedema: 20-80 mg as
a single dose daily or on alternate
days. Children: 1-2 mg/kg/day as single
dose.
Contraindications
Severe sodium and
water depletion, hypersensitivity to
sulphonamides and frusemide,
hypokalaemia, hyponatraemia, precomatose
states associated with liver cirrhosis,
Addison’s disease.
Presentations:
10 tablets
MRP Retailer
Stockist
3.80
3.04 2.73
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