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Each tablet contains:
Composition:
Gatifloxacin.....................................................................200
mg
Ornidazole......................................................................500
mg
Indications:
·
Respiratory tract infections like lung
abscess, aspiration pneumonia, empyema
and bronchiectasis.
·
ENT infections like chronic sinusitis,
chronic suppurative otitis media,
cholesteatoma and mastoiditis.
·
Dermatological infections like cellulitis, breast and other
cutaneous abscesses, gangrene and
decubitus ulcers. Orofacial and dental
infections.
·
Surgical wound infections.
·
Gynaecological infections including
Description:
Gatifloxacin, a new type of quinolone
antibiotic, has been approved by the
U.S. Food and Drug Administration for
indications including the treatment of
community-acquired respiratory tract
infections (RTIs). It was designed with
a unique 8-methoxy structure that
appears to enhance bactericidal action
and decrease the rate of the development
of resistance of gram-positive bacteria.
Quinolones rapidly inhibit DNA synthesis
by promoting cleavage of bacterial DNA
in the DNA-enzyme complexes of DNA
gyrase and type IV topoisomerase,
resulting in rapid bacterial death. As a
general rule, gram-negative bacterial
activity correlates with inhibition of
DNA gyrase, and gram-positive bacterial
activity corresponds with inhibition of
DNA type IV topoisomerase.
Quinolones inhibit two specific enzymes,
DNA gyrase and DNA topoisomerase IV,
which aid in bacterial DNA replication.
FACTIVE displays strong binding affinity
at both of these target sites, which
helps maintain high in vitro potency
against resistant
S
pneumoniae. This dual
targeting with FACTIVE is achievable at
therapeutic drug levels.
The antimicrobial activity of ornidazole is due
to the reduction of the nitro group to a
more reactive amine that attacks
microbial DNA, brings about loss of
helical structure of DNA and subsequent
DNA breakage thus inhibiting further
synthesis and causing degradation of
existing DNA.
contraindications
Gatifloxacin is contraindicated in
persons with a
history
of
hypersensitivity to
gatifloxacin or any
member
of the
quinolone
class
of
antimicrobial agents.
Ornidazole
is contraindicated in persons with a
history
of
hypersensitivity
ornidazole and other imidazoles.
Warnings and precautions
Special precautions are required in case
of ataxia, vertigo, mental confusion and
patients with neurological diseases.
There is need for adjustment of dosage
and dosage interval in patients with
hepatic impairment. Modification of the
usual dosage is not necessary in
patients of renal failure however,
additional post haemodialysis dose may
be required in patients undergoing this
procedure. ]
Dosage:
The recommended dosage for Gatimin-OZ
tablets is described below. Doses of
Gatimin-OZ are administered once every
24 hours.
Presentations: 10 tablets
MRP
Retailer Stockist
45.00 36.00 32.40
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