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Ear Drops
Composition:
Gentamicin I.P.............................................................
0.3% w/v
Clotrimazole..................................................................1%
w/v
Betamethasone Depropionate U.S.P.......................0.025%
w/v
Lignocaine HCL............................................................2%
w/v
In glycerin I.P & Propylene Glycol I.P............................q.s.
Indications :
Gentabet can cause severe hearing and
kidney problems. Gentabet eliminates
bacteria that cause many kinds of
infections, including lung, skin, bone,
joint, stomach, blood, and urinary tract
infections.
Description:
The binding of gentamicin (Gm) to
Escherichia coli ribosomes and ribosomal
subunits has been studied. By
means of equilibrium dialysis and of
statistical interpretation of the
data it was found that [3H]gentamicin C2
and 6'-N-[3H]methylgentamicin C1a
interact with three classes of sites on
tight-coupled 70-S species: a
first class concerning the tight and
non-cooperative interaction with
one drug molecule (Kd = 0.6 microM), a
second class in which about five
Gm molecules bind cooperatively (mean Kd
= 10 microM), and a third
class of very high capacity in which up
to 70 drug molecules may
interact. The extreme cooperativity of
the third class of sites
induces such an increase in the affinity
for Gm that it may allow the
shift of molecules already bound from
high-affinity sites towards
lower-affinity sites. The alteration of
a ribosomal protein, L6, in a
gentamicin- resistant mutant of E. coli
abolished the multiclass and the
cooperative aspects of
ribosomes--gentamicin interaction.
The large ribosomal subunits
from E. coli MRE 600 strain interact
cooperatively with Gm,
whereas 50-S particles from the
resistant mutant bind the drug in a
diffuse way with high capacity and
low affinity. The small subunits from
both strains behave identically
towards Gm. A good correlation is
observed in comparing the
gentamicin concentrations capable of
saturating the different
ribosomal classes of sites with
concentrations inducing its
multiphasic effects on protein
synthesis.
Dosage: As per
the physician’s advice.
Presentations:
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