Therapeutic Index

Each Tablet contains:
Metformin Hydrochloride................500mg

COMPOSITION :
GLUCORIDE 500
Each uncoated Extended release tablet contains:
Metformin Hydrochloride equivalent IP……………………500mg

GLUCORIDE 850
Each uncoated Extended-release tablet contains:
Metformin Hydrochloride equivalent IP……………………850mg

GLUCORIDE 1000
Each uncoated Extended-release tablet contains:
Metformin Hydrochloride equivalent IP………………….1000mg

INDICATIONS :
GLUCORIDE tablets, used as a once per day, are indicated as an adjunct to diet and exercise, to lower blood glucose. GLUCORIDE can be used concomitantly with a sulphonylurea or insulin to improve glycaemic control in adults.

GLUCORIDE is indicated in patients 17 years of age and older as either monotherapy or in combination therapy.

DOSAGE AND ADMINISTRATION :
There is no fixed dosage regimen for the management of hyperglycaemia in patients with type 2 diabetes with metformin or any other pharmacologic agent. Dosage of GLUCORIDE must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily dose.The maximum recommended daily dose of metformin extended release tablets in adults is 2000 mg/day.

GLUCORIDE should generally be given once daily with the evening meal. Metformin should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycaemic control of the patient. During treatment initiation and dose titration (see Recommended Dosing Schedule ) , fasting plasma glucose should be used to determine the therapeutic response to GLUCORIDE and identify the minimum effective dose for the patient.

 Thereafter, glycosylated haemoglobin should be measured at intervals of approximately three months. The therapeutic goal should be to decrease both fasting plasma glucose and glycosylated haemoglobin levels to normal or near normal by using the lowest effective dose of GLUCORIDE , either when used as monotherapy or in combination with sulphonylurea or insulin.

CONTRAINDICATIONS :
Metformin is contraindicated in patients with:

1. Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels >/=1.5 mg/dL [males], >/=1.4 mg/dL [females] or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia.
2. Congestive heart failure requiring pharmacologic treatment.
3. Known hypersensitivity to metformin.
4. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.

Metformin should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function

PACKAGING INFORMATION :
GLUCORIDE 500  ...............Strip of 10 tablets
GLUCORIDE 850  ...............Strip of 10 tablets
GLUCORIDE 1000 ..............Strip of 10 tablets


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