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Each tablet contains:
Composition:
Isoniazid (INH).................................................................300
mg
Indications:
Tuberculosis in children. Prophylaxis in children in contact
with open cases.
Description:
Mechanism of action Isoniazid is a
prodrug and must be activated by
bacterial catalase. The active form
inhibits the synthesis of mycolic acid
in the mycobacterial cell wall.
Isoniazid reaches therapeutic
concentrations in serum, cerebrospinal
fluid (CSF), and within caseous
granulomas. Isoniazid is metabolized in
the liver via acetylation. There are two
forms of the enzyme responsible for
acetylation, so that some patients
metabolize the drug quicker than others.
Hence, the half-life is bimodal with
peaks at 1 hour and 3 hours in the US
population. The metabolites are excreted
in the urine. Doses do not usually have
to be adjusted in case of renal failure.
Isoniazid is bactericidal to
rapidly-dividing mycobacteria, but is
bacteriostatic if the mycobacterium is
slow-growing. Side effects Adverse
reactions include rash, abnormal liver
function tests, hepatitis, sideroblastic
anemia, peripheral neuropathy, mild
central nervous system (CNS) effects,
and drug interactions resulting in
increased phenytoin (Dilantin) or
disulfiram (Antabuse) levels. Peripheral
neuropathy and CNS effects are
associated with the use of isoniazid and
are due to pyridoxine (vitamin B6)
depletion, but are uncommon at doses of
5 mg/kg. Persons with conditions in
which neuropathy is common (e.g.,
diabetes, uremia, alcoholism,
malnutrition, HIV-infection), as well as
pregnant women and persons with a
seizure disorder, may be given
pyridoxine (vitamin B6) (10-50 mg/day)
with isoniazid. Hepatoxicity can be
avoided with close Clinical monitoring
of the patient, Specifically Nausea,
Vomiting, Abdominal pain and appetite.
INH therapy will also decrease the
efficacy of hormonal birth control.
Side effects
Adverse reactions include
rash,
abnormal
liver
function tests,
hepatitis,
sideroblastic anemia,
peripheral neuropathy, mild
central
nervous system (CNS) effects,
and drug
interactions resulting in
increased
phenytoin (Dilantin) or
disulfiram (Antabuse) levels.
Peripheral neuropathy and
CNS
effects are associated with the use of
isoniazid and are due to
pyridoxine (vitamin B6)
depletion, but are uncommon at doses of
5 mg/kg. Persons with conditions in
which neuropathy is common (e.g.,
diabetes,
uremia,
alcoholism,
malnutrition,
HIV-infection),
as well as
pregnant
women and persons with a
seizure
disorder, may be given
pyridoxine (vitamin B6)
(10-50 mg/day) with isoniazid.
Hepatoxicity can be avoided with close
Clinical monitoring of the patient,
Specifically Nausea, Vomiting, Abdominal
pain and appetite.
INH therapy will also decrease the
efficacy of hormonal birth control.
Dosage : Adults: 3-5mg/kg body-wt. upto 300mg
daily in a single dose.
Children: 10-20mg/kg body-wt. daily in single
doses.
Presentations:
10 tablets
MRP Retailer Stockiest
4.95
3.96 3.56
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