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Each tablet contains :
Composition:
Atorvastatin……….........................................
10 mg
Atorvastatin……….........................................
20 mg
Indications :
Lipirol is a prescription drug. It is used in patients
with multiple risk factors for heart
disease such as family history, high
blood pressure, age ,low HDL or smoking
to reduce the risk of heart attack and
stroke. Lipirol is also used in
patients with type 2 diabetes and at
least one other risk factor for heart
disease such as high blood pressure,
smoking or complications of diabetes,
including eye disease and protein in
urine, to reduce the risk of heart
attack and stroke.
Description:
Atorvastatin (Lipitor) is a selective,
competitive inhibitor of HMG
CoA reductase, the rate-limiting enzyme
that converts 3-hydroxy
3-methylglutaryl-coenzyme A to
mevalonate, a precursor of
sterols, including cholesterol.
Cholesterol and triglycerides
circulate in the bloodstream as party of
lipoprotein complexes.
With ultracentrifugation, these
complexes separate into HDL
(high-density lipoprotein), IDL
(intermediate-density lipoprotein),
LDL (low-density lipoprotein), and VLDL
(very-low-density
lipoprotein) fractions.
Triglycerides (TG) and cholesterol in
the liver are incorporated into
VLDL and released into the plasma for
delivery to peripheral
tissues. LDL is formed from VLDL and is
catabolized primarily
through the high-affinity LDL receptor.
Clinical and pathologic
studies wshow that elevated plasma
levels of total cholestero
(total-C), LDL-cholesterol (LDL-C), and
apolipoprotein B (apo B)
promote human atherosclerosis and are
risk factors for
developing cardiovascular disease, while
increased levels of
HDL-C are associated with a decreased
cardiovascular risk.
In animal models, Atorvastatin (Lipitor)
lowers plasma cholesterol
and lipoprotein levels by inhibiting
HMG-CoA reductase and
cholesterol synthesis in the liver and
by increasing the number of
hepatic LDL receptors on the
cell-surface to enhance uptake and
catabolism of LDL; Atorvastatin (Lipitor)
also reduces LDL
production and the number of LDL
particles. Atorvastatin (Lipitor)
reduces LDL-C in some patients with
homozygous familial
hypercholesterolemia (FH), a population
that rarely responds to
other lipid-lowering medication.
A variety of clinical studies have
demonstrated that elevated levels
of total-C, LDL-C, and apo B (a membrane
complex for LDL-C)
promote human atherosclerosis.
Similarly, decreased levels of
HDL-C (and its transport complex, apo A)
are associated with the
development of atherosclerosis.
Epidemiologic investigations
have established that cardiovascular
morbidity and mortality vary
directly with the level of total-C and
LDL-C, and inversely with the
level of HDL-C. Although frequently
found in association with low
HDL-C, elevated plasma TG has not been
established as an
independent risk factor for coronary
heart disease. The
independent effect of of raising HDL-C
or lowering TG on the risk
fro coronary and cardiovascular
morbidity and mortality has not
been established.
Atorvastatin (Lipitor) reduces total-C,
LDL-C, and apo B in patients
with homozygous and heterozygous FH,
nonfamilial forms of
hypercholesterolemia, and mixed
dyslipidemia. Atorvastatin
(Lipitor) also reduces VLDL-C and TG and
produces variable
increases in HDL-C and apolipoprotein
A-1. The effect of
Atorvastatin (Lipitor) on cardiovascular
morbidity and mortality has
not been determined.
Like LDL, cholesterol-enriched
triglyceride-rich lipoproteins,
including VLDL, intermediate density
lipoprotein (IDL), and
remnants, can also promote
atherosclerosis. Elevated plasma
triglycerides are frequently found in a
triad with low HDL-C levels
and small LDL particles, as well as in
association with non-lipid
metabolic risk factors for coronary
heart disease. As such, total
plasma TG has not consistently been
shown to be an
independent risk factor for CHD.
Furthermore, the independent
effect of raising HDL or lowering TG on
the risk of coronary and
cardiovascular morbidity and mortality
has not been determined.
Dosage:
As per the physician’s advice.
Presentations:
MRP
Retailer Stockist
10
tablets 25.20
20.16 18.14
10
tablets 49.50
39.60 35.64
Wallpapers:
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