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Each film-coated tablet contains :
Composition:
Lamivudine
.....................................................................100
mg
Indications :
Lobivir HBV is indicated for the
treatment of chronic Hepatitis B and
evidence of hepatitis B virus (HBV)
replication in patients with
decompensated liver disease or active
inflammation and/or fibrosis.
Description:
Lamivudine (ß-L-2',3'-dideoxy-3'-thiacytidine), one
of the dideoxycytidine (ddC)
analogue NRTIs, is the first
nucleoside analogue approved to treat
chronic HBV infection and has
been shown to benefit various categories
of patients. These include
HBe-positive and -negative patients,
non-responders to interferon-
therapy, and patients with decompensated
cirrhosis.
Lamivudine’s D-isomer is less active against HBV
replication and more cytotoxic than the
L-isomer. Both the D- and
L-isomers of 2',3'-dideoxy-
3'-thiauridine were found to
be inactive against HBV replication, and
the susceptibility of the
thiacytidine stereoisomers to cytidine
and/or deoxycytidine
deaminase was suspected to be the
reason. In fact, the racemic
mixture and the D-isomer of
2',3'-dideoxy-3'-thiacytidine were
deaminated with partially purified
human deaminase and were
found to be processed to the
D-isomer of the thiauridine, while lamivudine and
ddC were not. Despite the intracellular
stability of its cytosine
base, ddC was less effective than
lamivudine in a cell culture
system. Until recently, it was thought
that the potency of
lamivudine reflected the higher
incorporation efficiency into
newly synthesized DNA by the viral DNA
polymerase. Lamivudine and
ddC are phosphorylated to their
triphosphates and then the
triphosphates act as chain terminators
during viral and cellular DNA
synthesis.
CONTRA-INDICATIONS:
EPIVIR Tablets and Oral Solution are contraindicated in
patients with previously demonstrated
clinically significant hypersensitivity
to any of the components of the
products.
Dosage: The recommended dosage of Lobivir HBV is 100 mg once daily
or as per the physician’s advice.
Presentations: 10
tablets
MRP Retailer Stockiest
820.00 656.00 590.40
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