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Each uncoated tablet contains:
Composition:
Misoprostol......................................................................200
mcg
Excipients..................................................................................q.s.
Indications:
Treatment of duodenal, gastric and NSAID induced ulceration.
Misobortol should be taken for the
duration of NSAID therapy.
Description:
Misoprostol is a synthetic analogue of naturally
occurring prostaglandin E1. It has been
approved in more than 90 countries for
prevention and treatment of gastric and
duodenal ulcers. Very few countries have
misoprostol registered as an abortion
pill. It is safe and well tolerated, and
can be kept at room temperature when
packed in aluminium blisters.
Outcome of treatment with misoprostol
when used orally or vaginally has shown
a complete abortion rate of 87% and 95%,
incomplete abortion 3% and 4%, missed
abortion 3% and 1% and continuing
pregnancy in 7% and 1% respectively.
Misoprostol is rapidly absorbed after
oral administration and converted to its
pharmacologically active metabolite,
misoprostol acid. Plasma concentrations
of misoprostol acid peak in
approximately 30 minutes and decline
rapidly thereafter.
The effects of misoprostol on the
reproductive tract are increased, and
gastrointestinal adverse effects are
decreased, if this is administered
vaginally. On vaginal administration,
the plasma concentrations of misoprostol
acid peaks in 1-2 hours and then
declines slowly. Vaginal application
results in slower increase and lower
peak plasma concentration of misoprostol
acid than does oral administration.
Uterine contractility increases and then
plateaus one hour after oral
administration, whereas, contractility
continues for four hours after vaginal
route.
Dosage :
The recommended adult oral dose for the treatment of
duodenal, gastric and NSAID induced
ulceration is 200 mcg 4 times daily with
food and at bedtime for 4-8 weeks.
If this dose is not tolerated, a dose of
100 mcg can be used.
Presentations:
4 tablets
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61.00 48.80 36.72
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