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Each uncoated tablet contains:
Composition:
Nimesulide B.P................................................................100
mg
Paracetamol I.P..............................................................325
mg
Excipients.................................................................................q.s.
Indications:
Painful inflammatory conditions namely
osteoarthritis, rheumatoid arthritis,
postoperative pain, dental pain.
Description:
Paracetamol acts by reducing production
of
prostaglandins, which
are involved in the pain and fever
processes, by inhibiting the
cyclooxygenase (COX)
enzyme .However, there
are important differences between the
effects of aspirin and those of
paracetamol. Prostaglandins participate
in the
inflammatory response
which is why aspirin has been known to
trigger symptoms in asthmatics, but
paracetamol has no appreciable
anti-inflammatory action and hence does
not have this side-effect. Furthermore,
the COX enzyme also produces
thromboxanes, which
aid in
blood clotting —
aspirin reduces blood clotting, but
paracetamol does not. Finally, aspirin
and the other NSAIDs commonly have
detrimental effects on the stomach
lining, where prostaglandins serve a
protective role, but paracetamol is
safe.
Indeed, while aspirin acts as an
irreversible
inhibitor of COX and directly blocks the
enzyme's
active site,
paracetamol indirectly blocks COX, and
this blockade is ineffective in the
presence of
peroxides.
This might explain why paracetamol is
effective in the
central nervous system
and in
endothelial cells
but not in
platelets
and
immune cells
which have high levels of peroxides.
Dosage :
1 tablet twice daily.
Presentations:
10 tablets
MRP Retailer Stockist
25.75 20.60
18.54 18.54
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