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Each film-coated tablet contains:
Composition:
Sildenafil
Citrate...............................................................100
mg
Indications :
NEOGRA is indicated for the treatment of
erectile dysfunction in men.
Description:
Part of the physiological process of
erection involves the parasympathetic
nervous system causing the release of
nitric
oxide (NO) in the
corpus
cavernosum of the penis. NO
binds to the receptors of the enzyme
guanylate cyclase which
results in increased levels of
cyclic
guanosine monophosphate (cGMP),
leading to
smooth
muscle relaxation (vasodilation)
in the corpus cavernosum, resulting in
increased inflow of blood and an
erection.
Sildenafil is a potent and selective
inhibitor of
cGMP
specific phosphodiesterase type 5
(PDE5) which is responsible for
degradation of cGMP in the
corpus
cavernosum. The molecular
structure of sildenafil is similar to
that of cGMP and acts as a competitive
binding agent of PDE5 in the corpus
cavernosum, resulting in more cGMP and
better erections. Without sexual
stimulation, and therefore lack of
activation of the NO/cGMP system,
sildenafil should not cause an erection.
Sildenafil is
metabolised by
hepatic
enzymes
and excreted by both the
liver
and
kidneys.
If taken with a high-fat meal, there may
be a delay in absorption of sildenafil
and the peak effect might be reduced
slightly as the plasma concentration
will be lowered
Contraindications
Use of
NEOGRA
is
contraindicated in patients with a known
hypersensitivity
to any component
of the tablet. Consistent with its known
effects on the
nitric oxide/cGMP
pathway, sildenafil was shown to
potentiate the
hypotensive
effects of nitrates, and its
administration to patients who are
concurrently
using organic nitrates in any form is
therefore contraindicated.
Dosage:
For most patients, the recommended dose
is 50 mg taken, as needed approximately
1 hour before sexual activity. However,
NEOGRA may be taken anywhere from 4
hours to 0.5 hour before sexual
activity. Based on effectiveness and
toleration, the dose may be increased to
a maximum recommended dose of 100 mg or
decreased to 25 mg. The maximum
recommended dosing frequency is once per
day.
Presentations: 4
Tablets
MRP
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