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Each Injection contains:
Composition:
Pantoprazole
..................................................................40
mg
Indications:
Protozole reduces the amount of
acid in the stomach and
duodenum. This helps to heal peptic
ulcers and helps to prevent
them from recurring. It also helps to
relieve the symptoms of
reflux oesophagitis.
Description:
Proton
pump inhibitors act by
irreversibly blocking the
hydrogen/potassium
adenosine triphosphatase
enzyme
system ( the
H+/K+
ATPase, or more commonly just
gastric
proton
pump)
of the gastric
parietal
cell. The proton pump is the
terminal stage
n gastric acid secretion, being directly
responsible for secreting H
+ ions into the gastric
lumen, making it an ideal target for
inhibiting
acid secretion.
Targeting the terminal-step in acid
production, as well as the
irreversible nature of the inhibition,
result in a class of drugs
t hat is significantly more effective
than
H2
antagonists and
reduces gastric acid secretion by up to
99%.
The lack of the acid in the stomach
will aid in the healing of
duodenal
ulcers, and reduces the pain from
indigestion and
h
eartburn, which can be
exacerbated by stomach acid. However,
lack of stomach acid may also contribute
to
hypochlorhydria, a la
c k of sufficient
hydrochloric acid, or HCl.
Hydrochloric acid is r
equired for absorption of nutrients,
particularly calcium.
The proton pump inhibitors are given in
an inactive form. The
inactive
form is neutrally charged (lipophilic)
and readily crosses
cell
membranes into intracellular
compartments (like the parietal
cell
canaliculus) that have acidic
environments. In an acid
environment,
the inactive drug is protonated and
rearranges into
its
active form. As described above, the
active form will
covalently
and
irreversibly bind to the gastric proton
pump, deactivating it.
Dosage: As per
the physician’s advice.
Presentation:
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