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Each capsule (E.C. granules ) contains:
Composition:
Omeprazol..................................................................20
mg
Indications:
Ulcer, duodenal; Adenoma, multiple
endocrine; Esophagitis, erosive;
Gastroesophageal Reflux Disease;
Mastocytosis, systemic; Ulcer, gastric;
Zollinger-Ellison syndrome; Pregnancy
Category C;
Description:
Omeprazole is a selective and
irreversible proton pump inhibitor.
Omeprazole suppresses gastric acid
secretion by specific inhibition of the
hydrogen–potassium
adenosinetriphosphatase (H +,
K +-ATPase) enzyme system
found at the secretory surface of
parietal cells. It inhibits the final
transport of hydrogen ions (via exchange
with potassium ions) into the gastric
lumen. Since the H +, K
+-ATPase enzyme system is regarded
as the acid (proton) pump of the gastric
mucosa, omeprazole is known as a gastric
acid pump inhibitor. The inhibitory
effect is dose-related. Omeprazole
inhibits both basal and stimulated acid
secretion irrespective of the stimulus.
Side/Adverse Effects
Note: Gastric fundic gland polyps
have occurred rarely in patients
receiving omeprazole; these appear to be
benign and reversible upon
discontinuance of omeprazole.
Gastroduodenal carcinoids have been
reported in patients with Zollinger-Ellison
syndrome who have received long-term
omeprazole therapy. These carcinoids are
believed to be a manifestation of the
underlying syndrome, which is known to
be associated with such tumors.
Atrophic gastritis has been noted
occasionally in gastric corpus biopsies
from patient receiving long-term
omeprazole therapy.
Overt liver disease has occurred rarely,
and included hepatocellular, cholestatic,
or mixed hepatitis, liver necrosis
(sometimes fatal), hepatic failure
(sometimes fatal), and hepatic
encephalopathy.
The following side/adverse effects have
been selected on the basis of their
potential clinical significance
(possible signs and symptoms in
parentheses where appropriate)—not
necessarily inclusive:
Contraindications
Omeprazole delayed-release capsules are
contraindicated in patients with known
hypersensitivity to any component of the
formulation
Dosage:
As per the physician’s advice.
Presentations: 10
caps
MRP
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