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Each kit contains:
Composition:
1 cap of Rifampicin..............................................450
mg
1 Tab of Ethambutol............................................800
mg
1 Tab of INH..........................................................150
mg
2 Tab of Pyrazinamide.........................................750
mg
Indications:
Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and
Streptomycin are used in medication and
management of Tuberculosis.
Description:
Rifampicin inhibits DNA-dependent
RNA
polymerase in bacterial cells
by binding its beta subunit, thus
preventing transcription of
messenger RNA (mRNA) and
subsequent translation to proteins.
Ethambutol is a synthetic,
bacteriostatic antitubercular agent.
Ethambutol diffuses into actively
growing mycobacteria cells such as
tubercle bacilli . It appears to inhibit
the synthesis of one or more
metabolites, thus impairing cell
metabolism, arresting multiplication,
and resulting in cell death.
INH is thought to work through its effects
on lipids (fats) and DNA within the
tuberculosis bacterium.
Pyrazinamide is a
prodrug
that stops the growth of
Mycobacterium tuberculosis.
M. tuberculosis has the enzyme
pyrazinamidase which is only active at
acidic
pH.
Pyrazinamidase converts pyrazinamide to
the active form, pyrazinoic acid.
Pyrazinoic acid inhibits the enzyme
fatty acid synthetase I, which is
required by the bacterium to synthesise
fatty
acids.
Dosage:
Adults: (below 50 kg): 450 mg daily as a single dose.
More than 50 kg: upto 600 mg daily.
Children: 10-15 mg /kg body wt. daily as single dose.
Presentations: 1 kit
MRP
Retailer Stockiest
14.10
11.28 10.15
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