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Each kit contains:
Composition:
1 cap of Rifampicin..........................................................100
mg
1 Tab of Pyrazinamide.....................................................300
mg
1 Tab of INH........................................................................50
mg
Indications :
Rifampicin, Ethambutol, Isoniazid,
Pyrazinamide and Streptomycin are used
in medication and management of
Tuberculosis.
Description:
Rifampicin inhibits DNA-dependent
RNA
polymerase in bacterial cells
by binding its beta subunit, thus
preventing transcription of
messenger RNA (mRNA) and
subsequent translation to proteins.
Pyrazinamide is a
prodrug
that stops the growth of
Mycobacterium tuberculosis.
M. tuberculosis has the enzyme
pyrazinamidase which is only active at
acidic
pH.
Pyrazinamidase converts pyrazinamide to
the active form, pyrazinoic acid.
Pyrazinoic acid inhibits the enzyme
fatty acid synthetase I, which is
required by the bacterium to synthesise
fatty
acids.
INH is thought to work through its effects
on lipids (fats) and DNA within the
tuberculosis bacterium.
Dosage :
Children : 10-15 mg /kg body wt. daily
as single dose.
Presentations : 1kit
MRP Retailer Stockist
6.75 5.40
4.86
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